Whole-transcriptome sequencing identifies a distinct subtype of acute lymphoblastic leukemia with predominant genomic abnormalities of EP300 and CREBBP

Chromosomal translocations are a genomic hallmark of many hematologic malignancies. Often as initiating events, these structural abnormalities result in fusion proteins involving transcription factors important for hematopoietic differentiation and/or signaling molecules regulating cell proliferatio...

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Vydáno v:Genome Res
Hlavní autoři: Qian, Maoxiang, Zhang, Hui, Kham, Shirley Kow-Yin, Liu, Shuguang, Jiang, Chuang, Zhao, Xujie, Lu, Yi, Goodings, Charnise, Lin, Ting-Nien, Zhang, Ranran, Moriyama, Takaya, Yin, Zhaohong, Li, Zhenhua, Quah, Thuan Chong, Ariffin, Hany, Tan, Ah Moy, Shen, Shuhong, Bhojwani, Deepa, Hu, Shaoyan, Chen, Suning, Zheng, Huyong, Pui, Ching-Hon, Yeoh, Allen Eng-Juh, Yang, Jun J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5287225/
https://ncbi.nlm.nih.gov/pubmed/27903646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.209163.116
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