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Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing
MRP RNA is an abundant, essential noncoding RNA whose functions have been proposed in yeast but are incompletely understood in humans. Mutations in the genomic locus for MRP RNA cause pleiotropic human diseases, including cartilage hair hypoplasia (CHH). Here we applied CRISPR–Cas9 genome editing to...
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| Vydáno v: | Genes Dev |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5287113/ https://ncbi.nlm.nih.gov/pubmed/28115465 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.286963.116 |
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