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Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing

MRP RNA is an abundant, essential noncoding RNA whose functions have been proposed in yeast but are incompletely understood in humans. Mutations in the genomic locus for MRP RNA cause pleiotropic human diseases, including cartilage hair hypoplasia (CHH). Here we applied CRISPR–Cas9 genome editing to...

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Bibliografske podrobnosti
izdano v:Genes Dev
Main Authors: Goldfarb, Katherine C., Cech, Thomas R.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5287113/
https://ncbi.nlm.nih.gov/pubmed/28115465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.286963.116
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