An RB insensitive to CDK regulation

The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays tumor cell growth. This novel mechanism of RB...

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Bibliografske podrobnosti
izdano v:Mol Cell Oncol
Main Authors: Joaquin, Manel, de Nadal, Eulàlia, Posas, Francesc
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Author's View
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286971/
https://ncbi.nlm.nih.gov/pubmed/28197540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1268242
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