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An RB insensitive to CDK regulation
The N-term phosphorylation of Retinoblastoma (RB) by the p38 stress-activated protein kinase (SAPK) makes RB insensitive to cyclin-dependent kinase (CDK)-Cyclin inhibition, which enhances the transcriptional repression of E2F-driven promoters and delays tumor cell growth. This novel mechanism of RB...
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| Publicado en: | Mol Cell Oncol |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Taylor & Francis
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5286971/ https://ncbi.nlm.nih.gov/pubmed/28197540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2016.1268242 |
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