The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo

BACKGROUND: The role of the chemokine CCL2 in breast cancer is controversial. While CCL2 recruits and activates pro-tumor macrophages, it is also reported to enhance neutrophil-mediated anti-tumor activity. Moreover, loss of CCL2 in early development enhances breast cancer progression. METHODS: To c...

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Bibliographic Details
Published in:BMC Cancer
Main Authors: Lavender, Nicole, Yang, Jinming, Chen, Sheau-Chiann, Sai, Jiqing, Johnson, C. Andrew, Owens, Philip, Ayers, Gregory D., Richmond, Ann
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286656/
https://ncbi.nlm.nih.gov/pubmed/28143493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3074-2
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