Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106

Expanded GGGGCC repeats in the first intron of the C9orf72 gene represent the most common cause of familial amyotrophic lateral sclerosis (ALS), but the mechanisms underlying repeat-induced disease remain incompletely resolved. One proposed gain-of-function mechanism is that repeat-containing RNA fo...

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Udgivet i:eLife
Main Authors: Celona, Barbara, von Dollen, John, Vatsavayai, Sarat C, Kashima, Risa, Johnson, Jeffrey R, Tang, Amy A, Hata, Akiko, Miller, Bruce L, Huang, Eric J, Krogan, Nevan J, Seeley, William W, Black, Brian L
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283830/
https://ncbi.nlm.nih.gov/pubmed/28072389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19032
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