Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat

Mutations in the synaptic gene SHANK3 lead to a neurodevelopmental disorder known as Phelan-McDermid syndrome (PMS). PMS is a relatively common monogenic and highly penetrant cause of autism spectrum disorder (ASD) and intellectual disability (ID), and frequently presents with attention deficits. Th...

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Udgivet i:eLife
Main Authors: Harony-Nicolas, Hala, Kay, Maya, du Hoffmann, Johann, Klein, Matthew E, Bozdagi-Gunal, Ozlem, Riad, Mohammed, Daskalakis, Nikolaos P, Sonar, Sankalp, Castillo, Pablo E, Hof, Patrick R, Shapiro, Matthew L, Baxter, Mark G, Wagner, Shlomo, Buxbaum, Joseph D
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2017
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283828/
https://ncbi.nlm.nih.gov/pubmed/28139198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18904
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