Deficiency of the immunostimulatory cytokine IL-21 promotes intestinal neoplasia via dysregulation of the Th1/Th17 axis

IL-21 has reported activity in promoting both Th1 and Th17 immune responses. Its role in sporadic human colorectal cancer is unknown. We aimed to delineate the role of IL-21 in a model of sporadic intestinal carcinogenesis. We found that in APC(MIN/+) mice, ablation of IL-21 increased intestinal tum...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Shapiro, Mia, Nandi, Bisweswar, Gonzalez, Gabriel, Prabhala, Rao H., Mashimo, Hiroshi, Huang, Qin, Frank, Natasha Y., Munshi, Nikhil C., Gold, Jason S.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2016
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283644/
https://ncbi.nlm.nih.gov/pubmed/28197386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1261776
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