A phase II trial of stereotactic body radiotherapy with concurrent anti-PD1 treatment in metastatic melanoma: evaluation of clinical and immunologic response

BACKGROUND: Antibodies blocking programmed cell death 1 (PD-1) have encouraging responses in patients with metastatic melanoma. Response to anti-PD-1 treatment requires pre-existing CD8+ T cells that are negatively regulated by PD-1-mediated adaptive immune resistance. Unfortunately, less than half...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: De Wolf, Katrien, Kruse, Vibeke, Sundahl, Nora, van Gele, Mireille, Chevolet, Ines, Speeckaert, Reinhart, Brochez, Lieve, Ost, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282822/
https://ncbi.nlm.nih.gov/pubmed/28137295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1123-x
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