Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells

A large number of drugs can induce prolongation of cardiac repolarization and life-threatening cardiac arrhythmias. The prediction of this side effect is however challenging as it usually develops in some genetically predisposed individuals with normal cardiac repolarization at baseline. Here, we de...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Stillitano, Francesca, Hansen, Jens, Kong, Chi-Wing, Karakikes, Ioannis, Funck-Brentano, Christian, Geng, Lin, Scott, Stuart, Reynier, Stephan, Wu, Ma, Valogne, Yannick, Desseaux, Carole, Salem, Joe-Elie, Jeziorowska, Dorota, Zahr, Noël, Li, Ronald, Iyengar, Ravi, Hajjar, Roger J, Hulot, Jean-Sébastien
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2017
Onderwerpen:
Human Biology and Medicine
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5279943/
https://ncbi.nlm.nih.gov/pubmed/28134617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19406
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