Are Prophylactic and Therapeutic Target Concentrations Different?: the Case of Lopinavir-Ritonavir or Lamivudine Administered to Infants for Prevention of Mother-to-Child HIV-1 Transmission during Breastfeeding

The ANRS 12174 trial assessed the efficacy and tolerance of lopinavir (LPV)-ritonavir (LPV/r) prophylaxis versus those of lamivudine (3TC) prophylaxis administered to breastfed infants whose HIV-infected mothers were not on antiretroviral therapy. In this substudy, we assessed LPV/r and 3TC pharmaco...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Foissac, Frantz, Blume, Jörn, Tréluyer, Jean-Marc, Tylleskär, Thorkild, Kankasa, Chipepo, Meda, Nicolas, Tumwine, James K., Singata-Madliki, Mandisa, Harper, Kim, Illamola, Silvia M., Bouazza, Naïm, Nagot, Nicolas, Van de Perre, Philippe, Blanche, Stéphane, Hirt, Déborah
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Pharmacology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278704/
https://ncbi.nlm.nih.gov/pubmed/27895016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01869-16
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