Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons

Fingolimod, also known as FTY720, is an analogue of the sphingolipid sphingosine, which has been proved to be neuroprotective in rodent models of Alzheimer’s disease (AD). Several cellular and molecular targets underlying the neuroprotective effects of FTY720 have been recently identified. However,...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Joshi, Pooja, Gabrielli, Martina, Ponzoni, Luisa, Pelucchi, Silvia, Stravalaci, Matteo, Beeg, Marten, Mazzitelli, Sonia, Braida, Daniela, Sala, Mariaelvina, Boda, Enrica, Buffo, Annalisa, Gobbi, Marco, Gardoni, Fabrizio, Matteoli, Michela, Marcello, Elena, Verderio, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278353/
https://ncbi.nlm.nih.gov/pubmed/28134307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41734
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