Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment

Resistance-associated substitutions (RASs) in hepatitis C virus (HCV) appear upon failure of treatment with direct-acting antivirals (DAAs). However, their origin has not been clarified in detail. Among 11 HCV genotype 1b patients who experienced virologic failure with asunaprevir (ASV)/daclatasvir...

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Vydáno v:Sci Rep
Hlavní autoři: Kai, Yugo, Hikita, Hayato, Morishita, Naoki, Murai, Kazuhiro, Nakabori, Tasuku, Iio, Sadaharu, Hagiwara, Hideki, Imai, Yasuharu, Tamura, Shinji, Tsutsui, Syusaku, Naito, Masafumi, Nishiuchi, Meiko, Kondo, Yasuteru, Kato, Takanobu, Suemizu, Hiroshi, Yamada, Ryoko, Oze, Tsugiko, Yakushijin, Takayuki, Hiramatsu, Naoki, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278351/
https://ncbi.nlm.nih.gov/pubmed/28134353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41660
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