Emergence of mmpT5 Variants during Bedaquiline Treatment of Mycobacterium intracellulare Lung Disease

Bedaquiline (BDQ), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections that no longer respond to conventional drugs. While investigating the off-label use of BDQ as salvage therapy, seven of 13 patients with Mycobacterium in...

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Detalhes bibliográficos
Publicado no:J Clin Microbiol
Main Authors: Alexander, David C., Vasireddy, Ravikiran, Vasireddy, Sruthi, Philley, Julie V., Brown-Elliott, Barbara A., Perry, Benjamin J., Griffith, David E., Benwill, Jeana L., Cameron, Andrew D. S., Wallace, Richard J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Mycobacteriology and Aerobic Actinomycetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5277528/
https://ncbi.nlm.nih.gov/pubmed/27927925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.02087-16
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