Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction

BACKGROUND: Transplantation of cardiosphere-derived cells (CDCs) has been shown to exert a therapeutic effect in patients with myocardial infarction (MI). However, poor survival of transplanted CDCs limits their beneficial effect. Metformin (MET) activates AMP-activated protein kinase (AMPK) which i...

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Dettagli Bibliografici
Pubblicato in:Stem Cell Res Ther
Autori principali: Yue, Rongchuan, Fu, Wenbin, Liao, Xiang, Lan, Cong, Liao, Qiao, Li, Liangpeng, Yang, Dezhong, Xia, Xuewei, Chen, Xiongwen, Zeng, Chunyu, Wang, Wei Eric
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5273815/
https://ncbi.nlm.nih.gov/pubmed/28129786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-017-0476-7
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