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Kinetics of insulin aggregation in aqueous solutions upon agitation in the presence of hydrophobic surfaces.

The stability of protein-based pharmaceuticals (e.g., insulin) is important for their production, storage, and delivery. To gain an understanding of insulin's aggregation mechanism in aqueous solutions, the effects of agitation rate, interfacial interactions, and insulin concentration on the overall...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Sluzky, V, Tamada, J A, Klibanov, A M, Langer, R
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1991
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52720/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1946348/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.21.9377
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