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Discovery of a (19)F MRI sensitive salinomycin derivative with high cytotoxicity towards cancer cells
Salinomycin is a promising anti-cancer agent which selectively targets cancer stem cells. To improve its potency and selectivity, an analogs library of salinomycin was generated by site-specific modification and CuAAc derivatization. Through a cytotoxicity analysis of the library, a fluorinated anal...
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| Publicado no: | Chem Commun (Camb) |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5271582/ https://ncbi.nlm.nih.gov/pubmed/26997457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc01508e |
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