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Beyond Rotatable Bond Counts: Capturing 3D Conformational Flexibility in a Single Descriptor

[Image: see text] A new molecular descriptor, nConf(20), based on chemical connectivity, is presented which captures the accessible conformational space of a molecule. Currently the best available two-dimensional descriptors for quantifying the flexibility of a particular molecule are the rotatable...

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Detalhes bibliográficos
Publicado no:J Chem Inf Model
Main Authors: Wicker, Jerome G. P., Cooper, Richard I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5271572/
https://ncbi.nlm.nih.gov/pubmed/28024401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.6b00565
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