Apolipoprotein E4 Elicits Lysosomal Cathepsin D Release, Decreased Thioredoxin-1 Levels, and Apoptosis

The major genetic risk factor for Alzheimer’s disease (AD), apolipoprotein E4 (ApoE4), has been suggested to have detrimental effects on neurons, including direct toxicity via apoptosis. Thioredoxin-1 (Trx1) is an endogenous antioxidant protein important for redox regulation and participates in the...

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Detalles Bibliográficos
Publicado en:J Alzheimers Dis
Autores principales: Persson, Torbjörn, Lattanzio, Francesca, Calvo-Garrido, Javier, Rimondini, Roberto, Rubio-Rodrigo, Marta, Sundström, Erik, Maioli, Silvia, Sandebring-Matton, Anna, Cedazo-Mínguez, Ángel
Formato: Artigo
Lenguaje:Inglês
Publicado: IOS Press 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5271484/
https://ncbi.nlm.nih.gov/pubmed/28035917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-150738
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