Leishmania HASP and SHERP Genes Are Required for In Vivo Differentiation, Parasite Transmission and Virulence Attenuation in the Host

Differentiation of extracellular Leishmania promastigotes within their sand fly vector, termed metacyclogenesis, is considered to be essential for parasites to regain mammalian host infectivity. Metacyclogenesis is accompanied by changes in the local parasite environment, including secretion of comp...

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Опубликовано в: :PLoS Pathog
Главные авторы: Doehl, Johannes S. P., Sádlová, Jovana, Aslan, Hamide, Pružinová, Kateřina, Metangmo, Sonia, Votýpka, Jan, Kamhawi, Shaden, Volf, Petr, Smith, Deborah F.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5271408/
https://ncbi.nlm.nih.gov/pubmed/28095465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006130
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