Using Model‐Based “Learn and Confirm” to Reveal the Pharmacokinetics‐Pharmacodynamics Relationship of Pembrolizumab in the KEYNOTE‐001 Trial

Evaluation of pharmacokinetic/pharmacodynamic (PK/PD) properties played an important role in the early clinical development of pembrolizumab. Because analysis of data from a traditional 3 + 3 dose‐escalation design revealed several critical uncertainties, a model‐based approach was implemented to be...

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Bibliografische gegevens
Gepubliceerd in:CPT Pharmacometrics Syst Pharmacol
Hoofdauteurs: Elassaiss‐Schaap, J, Rossenu, S, Lindauer, A, Kang, SP, de Greef, R, Sachs, JR, de Alwis, DP
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2016
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270295/
https://ncbi.nlm.nih.gov/pubmed/27863143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12132
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