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Do anti-amyloid beta protein antibody cross reactivities confound Alzheimer disease research?

BACKGROUND: Alzheimer disease (AD) research has focussed mainly on the amyloid beta protein (Aβ). However, many Aβ-and P3-type peptides derived from the amyloid precursor protein (APP) and peptides thought to derive from Aβ catabolism share sequence homology. Additionally, conformations can change d...

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Dades bibliogràfiques
Publicat a:J Negat Results Biomed
Autors principals: Hunter, Sally, Brayne, Carol
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5270220/
https://ncbi.nlm.nih.gov/pubmed/28126004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12952-017-0066-3
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