A Proof-of-Concept Trial of Protein Kinase C Iota Inhibition with Auranofin for the Paclitaxel-Induced Acute Pain Syndrome

PURPOSE: Paclitaxel causes the paclitaxel-induced acute pain (PIAP) syndrome. Based on preclinical data, we hypothesized that the protein kinase C (PKC) iota inhibitor, auranofin (a gold salt used for other pain conditions), palliates this pain. METHODS: In a randomized, double-blinded manner, patie...

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Detalhes bibliográficos
Publicado no:Support Care Cancer
Main Authors: Jatoi, Aminah, Grudem, Megan E., Dockter, Travis J., Block, Matthew S., Villasboas, Jose C., Tan, Angelina, Deering, Erin, Kasi, Pashtoon M., Mansfield, Aaron S., Botero, Juliana Perez, Okuno, Scott H., Smith, Deanne R., Fields, Alan P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269609/
https://ncbi.nlm.nih.gov/pubmed/27838777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00520-016-3467-9
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