Targeted delivery of an ADP-ribosylating bacterial toxin into cancer cells

The actin cytoskeleton is an attractive target for bacterial toxins. The ADP-ribosyltransferase TccC3 from the insect bacterial pathogen Photorhabdus luminescence modifies actin to force its aggregation. We intended to transport the catalytic part of this toxin preferentially into cancer cells using...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Zahaf , N.-I., Lang, A. E., Kaiser, L., Fichter, C. D., Lassmann, S., McCluskey, A., Augspach, A., Aktories, K., Schmidt, G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269596/
https://ncbi.nlm.nih.gov/pubmed/28128281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41252
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