TP53 mutations in newly diagnosed Acute Myeloid Leukemia –Clinico-molecular characteristics, response to therapy, and outcomes

BACKGROUND: TP53 gene mutations predict for poor prognosis in acute myeloid leukemia (AML). METHODS: Peripheral blood or bone marrow samples from 293 newly diagnosed AML patients were analysed with targeted amplicon-based next-generation sequencing based mutation analysis. RESULTS: We found TP53 mut...

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Publicado en:Cancer
Main Authors: Kadia, Tapan M., Jain, Preetesh, Ravandi, Farhad, Garcia-Manero, Guillermo, Andreef, Michael, Takahashi, Koichi, Borthakur, Gautam, Jabbour, Elias, Konopleva, Marina, Daver, Naval, Dinardo, Courtney, Pierce, Sherry, Shamanna Kanagal, Rashmi, Patel, Keyur, Estrov, Zeev, Cortes, Jorge, Kantarjian, Hagop
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269552/
https://ncbi.nlm.nih.gov/pubmed/27463065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30203
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