Integrating GWAS and Co-expression Network Data Identifies Causal Bone Mineral Density Genes SPTBN1 and MARK3 and an Osteoblast Functional Module

Bone mineral density (BMD) is a highly heritable predictor of osteoporotic fracture. Genome-wide association studies (GWAS) for BMD have identified dozens of associations; yet, the genes responsible for most associations remain elusive. Here, we used a bone co-expression network to predict causal ge...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Calabrese, Gina M., Mesner, Larry D., Stains, Joseph P., Tommasini, Steven M., Horowitz, Mark C., Rosen, Clifford J., Farber, Charles R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5269473/
https://ncbi.nlm.nih.gov/pubmed/27866947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2016.10.014
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