BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis

While 20–30% of colorectal cancers (CRCs) may arise from precursors with serrated glands, only 8–10% of CRCs manifest serrated morphology at diagnosis. Markers for distinguishing CRCs arising from ‘serrated’ versus ‘conventional adenoma’ precursors are lacking. We studied 36 human serrated CRCs and...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sakamoto, Naoya, Feng, Ying, Stolfi, Carmine, Kurosu, Yuki, Green, Maranne, Lin, Jeffry, Green, Megan E, Sentani, Kazuhiro, Yasui, Wataru, McMahon, Martin, Hardiman, Karin M, Spence, Jason R, Horita, Nobukatsu, Greenson, Joel K, Kuick, Rork, Cho, Kathleen R, Fearon, Eric R
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268782/
https://ncbi.nlm.nih.gov/pubmed/28072391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20331
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