Differential Feedback Regulation of Δ(4)-3-Oxosteroid 5β-Reductase Expression by Bile Acids

Δ(4)-3-oxosteroid 5β-reductase is member D1 of the aldo-keto reductase family 1 (AKR1D1), which catalyzes 5β-reduction of molecules with a 3-oxo-4-ene structure. Bile acid intermediates and most of the steroid hormones carry the 3-oxo-4-ene structure. Therefore, AKR1D1 plays critical roles in both b...

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Udgivet i:PLoS One
Main Authors: Valanejad, Leila, Nadolny, Christina, Shiffka, Stephanie, Chen, Yuan, You, Sangmin, Deng, Ruitang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268776/
https://ncbi.nlm.nih.gov/pubmed/28125709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170960
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