Knockdown of NIK and IKKβ-Binding Protein (NIBP) Reduces Colorectal Cancer Metastasis through Down-Regulation of the Canonical NF-κΒ Signaling Pathway and Suppression of MAPK Signaling Mediated through ERK and JNK

BACKGROUND: Despite the identification of many signaling pathways involved in colorectal cancer (CRC) tumorigenesis, metastatic CRC still remains one of the major causes of cancer related death. NIK and IKKβ-binding protein (NIBP) is one of the key regulators of the NF-κB signaling pathway, which ha...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Qin, Mengbin, Zhang, Jinxiu, Xu, Chunyan, Peng, Peng, Tan, Lin, Liu, Shiquan, Huang, Jiean
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268490/
https://ncbi.nlm.nih.gov/pubmed/28125661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170595
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