Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains

Clostridium difficile infections (CDI) are a leading cause of nosocomial diarrhea in the developed world. The main virulence factors of the bacterium are the large clostridial toxins (LCTs), TcdA and TcdB, which are largely responsible for the symptoms of the disease. Recent outbreaks of CDI have be...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:PLoS One
المؤلفون الرئيسيون: Secore, Susan, Wang, Su, Doughtry, Julie, Xie, Jinfu, Miezeiewski, Matt, Rustandi, Richard R., Horton, Melanie, Xoconostle, Rachel, Wang, Bei, Lancaster, Catherine, Kristopeit, Adam, Wang, Sheng-Ching, Christanti, Sianny, Vitelli, Salvatore, Gentile, Marie-Pierre, Goerke, Aaron, Skinner, Julie, Strable, Erica, Thiriot, David S., Bodmer, Jean-Luc, Heinrichs, Jon H.
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2017
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268477/
https://ncbi.nlm.nih.gov/pubmed/28125650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170640
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