N-Glycosylation of the Na+-Taurocholate Cotransporting Polypeptide (NTCP) Determines Its Trafficking and Stability and Is Required for Hepatitis B Virus Infection

The sodium/bile acid cotransporter NTCP was recently identified as a receptor for hepatitis B virus (HBV). NTCP is glycosylated and the role of glycans in protein trafficking or viral receptor activity is not known. NTCP contains two N-linked glycosylation sites and asparagine amino acid residues N5...

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Gepubliceerd in:PLoS One
Hoofdauteurs: Appelman, Monique D., Chakraborty, Anindita, Protzer, Ulrike, McKeating, Jane A., van de Graaf, Stan F. J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5268470/
https://ncbi.nlm.nih.gov/pubmed/28125599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170419
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