Heterotropic interactions in aspartate transcarbamoylase: turning allosteric ATP activation into inhibition as a consequence of a single tyrosine to phenylalanine mutation.

Aspartate transcarbamoylase (EC 2.1.3.2) is extensively studied as a model for cooperativity and allostery. This enzyme shows cooperativity between the catalytic sites, and its activity is feedback inhibited by CTP and activated by ATP. These regulatory processes involve several interfaces between c...

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Bibliografische gegevens

Gepubliceerd in:	Proc Natl Acad Sci U S A
Hoofdauteurs:	Van Vliet, F, Xi, X G, De Staercke, C, de Wannemaeker, B, Jacobs, A, Cherfils, J, Ladjimi, M M, Hervé, G, Cunin, R
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	National Academy of Sciences 1991
Onderwerpen:	Research Article
Online toegang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52676/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1924381/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.20.9180
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