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Preferential T-cell receptor beta-chain variable gene use in myelin basic protein-reactive T-cell clones from patients with multiple sclerosis.

Multiple sclerosis is an autoimmune disease in which T lymphocytes reactive to myelin basic protein (BP) could play a central role. T cells specific for BP were cloned from the blood of multiple sclerosis patients and normal individuals, and expression of T-cell receptor variable region genes was an...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Kotzin, B L, Karuturi, S, Chou, Y K, Lafferty, J, Forrester, J M, Better, M, Nedwin, G E, Offner, H, Vandenbark, A A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52672/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1717998/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.20.9161
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