Protease-Activated Receptor-1 Supports Locomotor Recovery by Biased Agonist Activated Protein C after Contusive Spinal Cord Injury

Thrombin-induced secondary injury is mediated through its receptor, protease activated receptor-1 (PAR-1), by "biased agonism." Activated protein C (APC) acts through the same PAR-1 receptor but functions as an anti-coagulant and anti-inflammatory protein, which counteracts many of the eff...

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Bibliographic Details
Published in:PLoS One
Main Authors: Whetstone, William D., Walker, Breset, Trivedi, Alpa, Lee, Sangmi, Noble-Haeusslein, Linda J., Hsu, Jung-Yu C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266300/
https://ncbi.nlm.nih.gov/pubmed/28122028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0170512
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