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Targeting of Wnt/β-Catenin by Anthelmintic Drug Pyrvinium Enhances Sensitivity of Ovarian Cancer Cells to Chemotherapy

BACKGROUND: Aberrant activation of Wnt/β-catenin has been shown to promote ovarian cancer proliferation and chemoresistance. Pyrvinium, an FDA-approved anthelmintic drug, has been identified as a potent Wnt inhibitor. Pyrvinium may sensitize ovarian cancer cells to chemotherapy. MATERIAL/METHODS: Th...

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Detalhes bibliográficos
Publicado no:Med Sci Monit
Main Authors: Zhang, Chongyuan, Zhang, Zhenge, Zhang, Shuirong, Wang, Wenrong, Hu, Ping
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266205/
https://ncbi.nlm.nih.gov/pubmed/28090074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.901667
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