Targeting of Wnt/β-Catenin by Anthelmintic Drug Pyrvinium Enhances Sensitivity of Ovarian Cancer Cells to Chemotherapy

BACKGROUND: Aberrant activation of Wnt/β-catenin has been shown to promote ovarian cancer proliferation and chemoresistance. Pyrvinium, an FDA-approved anthelmintic drug, has been identified as a potent Wnt inhibitor. Pyrvinium may sensitize ovarian cancer cells to chemotherapy. MATERIAL/METHODS: Th...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Med Sci Monit
Egile Nagusiak: Zhang, Chongyuan, Zhang, Zhenge, Zhang, Shuirong, Wang, Wenrong, Hu, Ping
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: International Scientific Literature, Inc. 2017
Gaiak:
Lab/In Vitro Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5266205/
https://ncbi.nlm.nih.gov/pubmed/28090074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.901667
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