G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis

In addition to oncogenic drivers, signaling nodes can critically modulate cancer-related cellular networks to strength tumor hallmarks. We identify G-protein-coupled receptor kinase 2 (GRK2) as a relevant player in breast cancer. GRK2 is up-regulated in breast cancer cell lines, in spontaneous tumor...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Nogués, Laura, Reglero, Clara, Rivas, Verónica, Salcedo, Alicia, Lafarga, Vanesa, Neves, Maria, Ramos, Paula, Mendiola, Marta, Berjón, Alberto, Stamatakis, Kostas, Zhou, Xiao Zhen, Lu, Kun Ping, Hardisson, David, Mayor, Federico, Penela, Petronila
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264252/
https://ncbi.nlm.nih.gov/pubmed/27720394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.09.030
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