Simvastatin promotes NPC1‐mediated free cholesterol efflux from lysosomes through CYP7A1/LXRα signalling pathway in oxLDL‐loaded macrophages

Statins, 3‐hydroxyl‐3‐methylglutaryl coenzyme A reductase inhibitors, are the first‐line medications prescribed for the prevention and treatment of coronary artery diseases. The efficacy of statins has been attributed not only to their systemic cholesterol‐lowering actions but also to their pleiotro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Mol Med
Prif Awduron: Xu, Xiaoyang, Zhang, Aolin, Halquist, Matthew S., Yuan, Xinxu, Henderson, Scott C., Dewey, William L., Li, Pin‐Lan, Li, Ningjun, Zhang, Fan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Original Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5264135/
https://ncbi.nlm.nih.gov/pubmed/27629819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.12970
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