Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

Lymphocytes circulate through lymph nodes (LN) in search for antigen in what is believed to be a continuous process. Here, we show that lymphocyte migration through lymph nodes and lymph occurred in a non-continuous, circadian manner. Lymphocyte homing to lymph nodes peaked at night onset, with cell...

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Vydáno v:Immunity
Hlavní autoři: Druzd, David, Matveeva, Olga, Ince, Louise, Harrison, Ute, He, Wenyan, Schmal, Christoph, Herzel, Hanspeter, Tsang, Anthony H., Kawakami, Naoto, Leliavski, Alexei, Uhl, Olaf, Yao, Ling, Sander, Leif Erik, Chen, Chien-Sin, Kraus, Kerstin, de Juan, Alba, Hergenhan, Sophia Martina, Ehlers, Marc, Koletzko, Berthold, Haas, Rainer, Solbach, Werner, Oster, Henrik, Scheiermann, Christoph
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5263259/
https://ncbi.nlm.nih.gov/pubmed/28087238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.12.011
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