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Conditional knockout of TOG results in CNS hypomyelination
The tumor overexpressed gene (TOG) protein is present in RNA granules that transport myelin basic protein (MBP) mRNA in oligodendrocyte processes to the myelin compartment. Its role was investigated by conditionally knocking it out (KO) in myelinating glia in vivo. TOG KO mice have severe motor defi...
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| Pubblicato in: | Glia |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5262536/ https://ncbi.nlm.nih.gov/pubmed/28063167 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.23106 |
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