Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells

Expression of the αvβ6 integrin is upregulated in several solid tumors. In contrast, physiologic expression of this epithelial-specific integrin is restricted to development and epithelial re-modeling. Here, we describe, for the first time, the development of a chimeric antigen receptor (CAR) that c...

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Pubblicato in:Mol Ther
Autori principali: Whilding, Lynsey M., Parente-Pereira, Ana C., Zabinski, Tomasz, Davies, David M., Petrovic, Roseanna M.G., Kao, Y. Vincent, Saxena, Shobhit A., Romain, Alex, Costa-Guerra, Jose A., Violette, Shelia, Itamochi, Hiroaki, Ghaem-Maghami, Sadaf, Vallath, Sabari, Marshall, John F., Maher, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5261028/
https://ncbi.nlm.nih.gov/pubmed/28129120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.10.012
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