Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB

Lipid catabolism disorder is the primary cause of atherosclerosis. Transcription factor EB (TFEB) prevents atherosclerosis by activating macrophage autophagy to promote lipid degradation. Hypericin-mediated sonodynamic therapy (HY-SDT) has been proved non-invasively inducing THP-1-derived macrophage...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Li, Xuesong, Zhang, Xin, Zheng, Longbin, Kou, Jiayuan, Zhong, Zhaoyu, Jiang, Yueqing, Wang, Wei, Dong, Zengxiang, Liu, Zhongni, Han, Xiaobo, Li, Jing, Tian, Ye, Zhao, Yajun, Yang, Liming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260986/
https://ncbi.nlm.nih.gov/pubmed/28005078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.433
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