De-ubiquitinating enzyme, USP11, promotes transforming growth factor β-1 signaling through stabilization of transforming growth factor β receptor II

The transforming growth factor β-1 (TGFβ-1) signaling pathway plays a central role in the pathogenesis of pulmonary fibrosis. Two TGFβ-1 receptors, TβRI and TβRII, mediate this pathway. TβRI protein stability, as mediated by the ubiquitin/de-ubiquitination system, has been well studied; however, the...

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Bibliographic Details
Published in:Cell Death Dis
Main Authors: Jacko, A M, Nan, L, Li, S, Tan, J, Zhao, J, Kass, D J, Zhao, Y
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260874/
https://ncbi.nlm.nih.gov/pubmed/27853171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.371
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