Inhibitory effects of hesperetin on Nav1.5 channels stably expressed in HEK 293 cells and on the voltage-gated cardiac sodium current in human atrial myocytes

AIM: Voltage-gated sodium channels composed of a pore-forming α subunit and auxiliary β subunits are responsible for the upstroke of the action potential in cardiac myocytes. The pore-forming subunit of the cardiac sodium channel Nav1.5, which is encoded by SCN5A, is the main ion channel that conduc...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Wang, Huan, Wang, Hong-fei, Zhang, Hao, Wang, Chen, Chen, Yu-fang, Ma, Rong, Xiang, Ji-zhou, Du, Xin-ling, Tang, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260836/
https://ncbi.nlm.nih.gov/pubmed/27694909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2016.97
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