The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA.

The polymeric immunoglobulin receptor (pIgR) on mucosal epithelial cells binds dimeric IgA (dIgA) on the basolateral surface and mediates transport of dIgA to the apical surface. Using Madin-Darby canine kidney epithelial cells stably transfected with pIgR cDNA, we found that soluble immune complexe...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Kaetzel, C S, Robinson, J K, Chintalacharuvu, K R, Vaerman, J P, Lamm, M E
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1991
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52597/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1924341/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8796
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