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Adaptive Randomization of Neratinib in Early Breast Cancer

BACKGROUND: I-SPY2, a standing, multicenter, adaptive phase 2 neoadjuvant trial ongoing in high-risk clinical stage II/III breast cancer, is designed to evaluate multiple, novel experimental agents added to standard chemotherapy for their ability to improve the rate of pathologic complete response (...

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Publicado en:N Engl J Med
Autores principales: Park, John W., Liu, Minetta C., Yee, Douglas, Yau, Christina, van 't Veer, Laura J., Symmans, W. Fraser, Paoloni, Melissa, Perlmutter, Jane, Hylton, Nola M., Hogarth, Michael, DeMichele, Angela, Buxton, Meredith B., Chien, A. Jo, Wallace, Anne M., Boughey, Judy C., Haddad, Tufia C., Chui, Stephen Y., Kemmer, Kathleen A., Kaplan, Henry G., Isaacs, Claudine, Nanda, Rita, Tripathy, Debasish, Albain, Kathy S., Edmiston, Kirsten K., Elias, Anthony D., Northfelt, Donald W., Pusztai, Lajos, Moulder, Stacy L., Lang, Julie E., Viscusi, Rebecca K., Euhus, David M., Haley, Barbara B., Khan, Qamar J., Wood, William C., Melisko, Michelle, Schwab, Richard, Lyandres, Julia, Davis, Sarah E., Hirst, Gillian L., Sanil, Ashish, Esserman, Laura J., Berry, Donald A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5259558/
https://ncbi.nlm.nih.gov/pubmed/27406346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1513750
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