Simian virus 40 small t antigen is not required for the maintenance of transformation but may act as a promoter (cocarcinogen) during establishment of transformation in resting rat cells.

Simian virus 40 deletion mutants affecting the 20,000-dalton (20K) t antigen and tsA mutants rendering the 90K T antigen temperature sensitive, as well as double mutants containing both mutations, induced host DNA synthesis in resting rat cells at the restrictive temperature. Nonetheless, the deleti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Seif, R, Martin, R G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1979
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC525947/
https://ncbi.nlm.nih.gov/pubmed/229274
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