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The effect of hydroxymethylcytosine on the structure and stability of Holliday junctions

5-Hydroxymethylcytosine ((5hm)C) is an epigenetic marker that has recently been shown to promote homologous recombination (HR). In this study, we determine the effects of (5hm)C on the structure, thermodynamics, and conformational dynamics of the Holliday junction (the four-stranded DNA intermediate...

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Vydáno v:Biochemistry
Hlavní autoři: Vander Zanden, Crystal M., Rowe, Rhianon K., Broad, Amanda J., Robertson, Adam B., Ho, P. Shing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5258817/
https://ncbi.nlm.nih.gov/pubmed/27653243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00801
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