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The effect of hydroxymethylcytosine on the structure and stability of Holliday junctions

5-Hydroxymethylcytosine ((5hm)C) is an epigenetic marker that has recently been shown to promote homologous recombination (HR). In this study, we determine the effects of (5hm)C on the structure, thermodynamics, and conformational dynamics of the Holliday junction (the four-stranded DNA intermediate...

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Publicat a:Biochemistry
Autors principals: Vander Zanden, Crystal M., Rowe, Rhianon K., Broad, Amanda J., Robertson, Adam B., Ho, P. Shing
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5258817/
https://ncbi.nlm.nih.gov/pubmed/27653243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00801
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