MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9

Siglec-9 is a sialic acid binding lectin predominantly expressed on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers resulting in increased sialylation. Thus when MUC1 is expressed on cancer cells it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Beatson, Richard, Tajadura-Ortega, Virginia, Achkova, Daniela, Picco, Gianfranco, Tsourouktsoglou, Theodora-Dorita, Klausing, Sandra, Hillier, Matthew, Maher, John, Noll, Thomas, Crocker, Paul R., Taylor-Papadimitriou, Joyce, Burchell, Joy M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5257269/
https://ncbi.nlm.nih.gov/pubmed/27595232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3552
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