MUC1 modulates the tumor immune microenvironment through the engagement of Siglec-9

Siglec-9 is a sialic acid binding lectin predominantly expressed on myeloid cells. Aberrant glycosylation occurs in essentially all types of cancers resulting in increased sialylation. Thus when MUC1 is expressed on cancer cells it is decorated by multiple short, sialylated O-linked glycans (MUC1-ST...

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Publicat a:Nat Immunol
Autors principals: Beatson, Richard, Tajadura-Ortega, Virginia, Achkova, Daniela, Picco, Gianfranco, Tsourouktsoglou, Theodora-Dorita, Klausing, Sandra, Hillier, Matthew, Maher, John, Noll, Thomas, Crocker, Paul R., Taylor-Papadimitriou, Joyce, Burchell, Joy M.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5257269/
https://ncbi.nlm.nih.gov/pubmed/27595232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3552
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