Mice lacking β-carotene-15,15’-dioxygenase exhibit reduced serum testosterone, prostatic androgen receptor signaling, and prostatic cellular proliferation

β-Carotene-15,15’-dioxygenase (BCO1) cleaves dietary carotenoids at the central 15,15’ double bond, most notably acting on β-carotene to yield retinal. However, Bco1 disruption also impacts diverse physiological end points independent of dietary carotenoid feeding, including expression of genes cont...

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Detalhes bibliográficos
Publicado no:Am J Physiol Regul Integr Comp Physiol
Main Authors: Smith, Joshua W., Ford, Nikki A., Thomas-Ahner, Jennifer M., Moran, Nancy E., Bolton, Eric C., Wallig, Matthew A., Clinton, Steven K., Erdman, John W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Hormones, Reproduction and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5256971/
https://ncbi.nlm.nih.gov/pubmed/27629887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00261.2016
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