Glucocorticoid receptor DNA-binding specificity is increased by the organization of DNA in nucleosomes.
A DNA fragment containing glucocorticoid receptor binding sites in the mouse mammary tumor virus promoter was reconstituted in vitro with histones to form nucleosome cores, which become positioned on the DNA fragment in a sequence-specific manner. Glucocorticoid receptor binding to specific DNA sequ...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Hovedforfatter: | |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1992
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525595/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1570308/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.9.3884 |
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